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1 December 2025

Nociplastic pain, a subtype of chronic pain, arises from altered nociception in the absence of clear tissue damage. Its poorly understood pathogenesis and the limited efficacy of current treatments underscore the urgent need for identifying and validating innovative pharmacological approaches that target central neurobiological pathways involved in pain processing.

2
Molecules for free

25 November 2025

By regulating intracellular cGMP levels, phosphodiesterase-9 (PDE9) plays a critical role in neuronal signaling, vascular function, and cell survival. By making our potent, selective, and brain-penetrant PDE9 inhibitor, BI 409306 (osoresonontrine) available to scientists free of charge, we incentivize new research to fully understand the role of the molecule in the context of disease.

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17 November 2025

A large portion of the proteome remains “undruggable” with traditional small molecules and biologics. To expand the druggable target landscape in areas of high unmet medical needs, novel innovative approaches could focus on targeting intracellular mechanisms, such as influencing nuclear translocation, organelle routing, molecular condensates, and spatial-temporal control mechanisms.

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20 October 2025

The Boehringer Ingelheim ChemKit initiative, provides open access to high-quality, structurally diverse, and drug-relevant building blocks. These structurally diverse building blocks enable the validation of novel chemical transformations in complex synthesis, stimulating research on innovative methodologies to overcome current limitations in chemical science.

32
Molecules for free

9 October 2025

opnMe now offers 100 well-characterized preclinical molecules for free to researchers worldwide. Since 2017, the program has supported over 10,000 orders from 54 countries, contributing to more than 240 scientific publications and advancing research across various fields. Explore the full collection of molecules today.

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