54
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02 December 2024

Cancers represent complex ecosystems that include tumor cells and a variety of non-cancerous cells such as immune cells, stroma cells, and other cell types present in the surrounding tissues, all embedded in a modified extracellular matrix. This environment within and around the tumor is known as the tumor microenvironment (TME).

66
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09 September 2024

The Fms-like tyrosine kinase 3 (FLT3) receptor is expressed by bone marrow progenitors at different stages of lymphoid and myeloid development. When the natural ligand binds to the FLT3 receptor, it triggers receptor dimerization...

23
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01 July 2024

Technical advances in genome sequencing, including long read sequencing, became very popular in recent years allowing us to overcome technical challenges in linking disease phenotypes to nucleotide polymorphisms. For the first time, we are...

43
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06 May 2024

The visual impairment caused by various diseases significantly impacts the quality of patients` life. The eye is a very sensitive organ with a sophisticated physiology and is composed of anterior and posterior segments. Especially the administration...

37
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08 April 2024

TRPA1 (transient receptor potential cation channel, subfamily A, member 1) is a cation channel expressed in the plasma membrane of multiple cell types, including a sub-population of primary sensory neurons as well as in non-neuronal cells such as...

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