Success examples
Characterization of a pleomorphic rhabdomyosarcoma cell line

Stickler S., Lang C., Rieche M., Eggerstorfer M-T., Hohenegger M., Hochmair M., Hamilton G.

Sci Rep. 2025, 15(1):2893.

GSK-3 inhibitor
DOI
PubMed
Success examples
A stromal inflammasome Ras safeguard against Myc-driven lymphomagenesis

Kent A., Yee Mon K. J., Hutchins Z., Putzel G., Zhigarev D., Grier A., Jia B., Kortlever R. M., Barbet G., Evan G. I., Blander J. M.

Nat Immunol. 2025, 26(1):53-67.

KRAS switch I/II pocket inhibitor
DOI
PubMed
Success examples
Radiation therapy promotes unsaturated fatty acids to maintain survival of glioblastoma

De Martino M., Daviaud C., Minns H. E., Lazarian A., Wacker A., Costa A. P., Attarwala N., Chen Q., Choi S-W., Rabadàn R., McIntire L. B. J., Gartrell R. D., Kelly J. M., Laiakis E. C., Vanpouille-Box C.

Cancer Lett. 2023, 570:216329.

FAS inhibitor
DOI
PubMed
Success examples
The efflux pump ABCC1/MRP1 constitutively restricts PROTAC sensitivity in cancer cells

Wolf G., Craigon C., Teoh S. T., Essletzbichler P., Onstein S., Cassidy D., Uijttewaal E. C. H., Dvorak V., Cao Y., Bensimon A., Elling U., Ciulli A., Superti-Furga G.

Cell Chem Biol. 2025, 32(2):291-306.e6.

BET PROTAC
DOI
PubMed
Success examples
Recent advances in the development of 17beta-hydroxysteroid dehydrogenase inhibitors

Poirier D.

Steroids. 2025, 213:109529.

DOI
PubMed
Success examples
Targeting of MMP-13 prevents aortic aneurysm formation in Marfan mice

Zimmermann LM. A., Furlan A.G., Mehrkens D., Geißen S., Zuk A.V., Pryymachuk G., Pykarek N., van Beers T., Sonntag-Bensch D., Marzi J., Schenke-Layland K., Brinckmann J., Zigrino P., Grandoch M., Baldus S., Sengle G.

bioRxiv 2022, 518511.

MMP-13 antagonist
DOI