Success examples
Advancing PROTAC Characterization: Structural Insights through Adducts and Multimodal Tandem-MS Strategies

Rahman M., Marzullo B., Holman S. W., Barrow M., Ray A. D., O’Connor P. B.

J. Am. Soc. Mass Spectrom. 2024, 35, 2, 285–299. open access

BRD7/BRD9 PROTAC
DOI
Success examples
A platform to induce and mature biomolecular condensates using chemicals and light

Hernandez-Candia C. N., Brady B. R., Harrison E., Tucker C. L.

Nat Chem Biol. 2024. 54(1):193-202.

BCL6 degrader BCL6 inhibitor
DOI
PubMed
Success examples
Activation of AMPK & p38MAPK Pathways with a Novel Agonistic Compound in LHCN-M2 Skeletal Muscle Myotubes

Brett R., Beall C., Hodson L., Renshaw D., Turner M.

Endocrine Abstracts 2023, 94 P59.

AMPK Activator
DOI
Success examples
Pharmacological inhibition of the cysteine protease cathepsin C improves graft function after heart transplantation in rats

Liu B., Korkmaz B., Kraft P., Mayer T., Sayour A. A., Grundl M. A., Domain R., Karck M., Szabó G., Korkmaz-Icöz S.

J Transl Med. 2023, 21(1):799.

Cathepsin C inhibitor
DOI
PubMed
Success examples
Cx43 can form functional channels at the nuclear envelope and modulate gene expression in cardiac cells

Martins-Marques T., Witschas K., Ribeiro I., Zuzarte M., Catarino S., Ribeiro-Rodrigues T., Caramelo F., Aasen T., Carreira I. M., Goncalves L., Leybaert L., Girao H.

Open Biol. 2023, 13(11):230258.

GSK-3 inhibitor
DOI
PubMed
Success examples
Molecular replacement for small-molecule crystal structure determination from X-ray and electron diffraction data with reduced resolution

Gorelik T. E., Lukat P., Kleeberg C., Blankenfeldt W., Mueller R.

Acta Crystallogr A Found Adv. 2023, 79(Pt 6):504-514.

BCL6 inhibitor
DOI
PubMed