Success examples
BI-3231, an enzymatic-inhibitor of HSD17B13, reduces lipotoxic effects induced by palmitic acid in murine and human hepatocytes

Alcober-Boquet L., Kraus N., Huber L. S., Vutukuri R., Fuhrmann D. C., Stross C., Schaefer L., Scholich K., Zeuzem S., Piiper A., Schulz M. H., Trebicka J., Welsch C., Ortiz C.

Am J Physiol Cell Physiol. 2024, 326(3):C880-C892.

HSD17B13 inhibitor
DOI
PubMed
Success examples
Advancing PROTAC Characterization: Structural Insights through Adducts and Multimodal Tandem-MS Strategies

Rahman M., Marzullo B., Holman S. W., Barrow M., Ray A. D., O’Connor P. B.

J. Am. Soc. Mass Spectrom. 2024, 35, 2, 285–299. open access

BRD7/BRD9 PROTAC
DOI
Success examples
A platform to induce and mature biomolecular condensates using chemicals and light

Hernandez-Candia C. N., Brady B. R., Harrison E., Tucker C. L.

Nat Chem Biol. 2024. 54(1):193-202.

BCL6 degrader BCL6 inhibitor
DOI
PubMed
Success examples
Activation of AMPK & p38MAPK Pathways with a Novel Agonistic Compound in LHCN-M2 Skeletal Muscle Myotubes

Brett R., Beall C., Hodson L., Renshaw D., Turner M.

Endocrine Abstracts 2023, 94 P59.

AMPK Activator
DOI
Success examples
Pharmacological inhibition of the cysteine protease cathepsin C improves graft function after heart transplantation in rats

Liu B., Korkmaz B., Kraft P., Mayer T., Sayour A. A., Grundl M. A., Domain R., Karck M., Szabó G., Korkmaz-Icöz S.

J Transl Med. 2023, 21(1):799.

Cathepsin C inhibitor
DOI
PubMed
Success examples
Cx43 can form functional channels at the nuclear envelope and modulate gene expression in cardiac cells

Martins-Marques T., Witschas K., Ribeiro I., Zuzarte M., Catarino S., Ribeiro-Rodrigues T., Caramelo F., Aasen T., Carreira I. M., Goncalves L., Leybaert L., Girao H.

Open Biol. 2023, 13(11):230258.

GSK-3 inhibitor
DOI
PubMed