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BI‑3757 is a cereblon (CRBN) binder that stabilizes CRBN in its open conformation. BI‑4506 is a structurally similar analog that does not bind CRBN and is available as a negative control.
HC-070 is a selective TRPC4/5 inhibitor that reduces calcium influx to restore neuronal balance. It is a valuable tool for exploring TRPC4/5 biology in the CNS and peripheral tissues where dysregulated channel activity may impact physiological processes.
BI‑9222 is a potent and selective Phosphoinositide-3-kinase gamma (PI3Kγ) inhibitor that modulates GPCR‑driven immune signaling, regulating cell migration, inflammation, and immune responses. BI‑9183 is available as its negative control.
Inhibition of PDE9 is expected to restore physiological cGMP levels in neurons, thereby enhancing NMDA receptor signaling and synaptic plasticity. BI 409306 (osoresnontrine) is a highly selective oral PDE9 inhibitor and BI-8777 an inactive analog which serves as a negative control.
Vanin 1 and vanin 2 regulate redox homeostasis and play essential roles in maintaining oxidative balance and modulating inflammation. For further research, we offer BI-4122, a dual vanin 1/2 inhibitor optimized for intravenous and oral administration.