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BI 831266 is a potent and selective Aurora B inhibitor that inhibits cell proliferation and could be used as a tool compound for testing biological hypotheses.
BI 653048 is a “dissociated” GR agonist (displaying different transcriptional regulatory profiles between gene transrepression and transactivation) with selectivity for other nuclear receptors (MR, PR) and good drug-like properties.
Our compound is the first small molecule inhibitor of the Chemokine receptor CCR10.1-3 It is a potent and selective compound and suitable for in vivo validation.
CCR1 is a key chemokine receptor for human monocyte/macrophage chemotaxis. BI-639667 blocks influx of pro-inflammatory cells to the site of inflammation.
BI-1388 is a nanomolar to picomolar inhibitor of Hepatitis C Virus (HCV) NS3 protease activity and of viral replication for various HCV genotypes and for resistant mutants D168V and R155K.