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Faldaprevir (BI 201335) is a highly potent and selective Hepatitis C Virus (HCV) NS3-NS4A protease inhibitor for pre-clinical research purposes . It is a highly optimized noncovalent competitive inhibitor of NS3-NS4A proteases (HCV genotypes 1a and 1b) with Ki values in the low nanomolar range.
VZ185 is a first-in-class low-molecular-weight VHL-based PROTAC (proteolysis-targeting chimera) degrader of the BAF/PBAF complexes subunits BRD7 and BRD9.
BIIL 315 is a highly potent LTB4 receptor antagonist (Ki = 1.9 nM).1 It is the active metabolite of the in vivo tool compound BIIL 284 and is the ideal tool to study LTB4 antagonism in vitro.
Prodrug BIIL 284 represents an excellent compound to study the effect of LTB4 receptor antagonism in vivo. After p.o.
BI-0588 is one of the most potent and specific allosteric inhibitors of Hepatitis C Virus (HCV) polymerase known, as demonstrated by its cell-based antiviral replicon activity in the single-digit nM range for genotype(GT)-1.