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Vanin 1 and vanin 2 regulate redox homeostasis and play essential roles in maintaining oxidative balance and modulating inflammation. For further research, we offer BI-4122, a dual vanin 1/2 inhibitor optimized for intravenous and oral administration.
mGluR1 PAMs restore cortical inhibitory tone and improve cognition in models of NMDA receptor hypofunction. To support research into mGluR1 function, we offer BI02982816 and its optimized reiteration, BI-1752 — two selective mGluR1 PAMs.
BI-3972 is a potent and selective small-molecule agonist of the calcium-activated potassium channel Slowpoke 1 (SLO-1), which is ubiquitously expressed in metazoans and involved in diverse physiological processes. The structurally related analog BI-4083 serves as a negative control.
BI-0282 is a small molecule antagonist of the MDM2 and p53 protein-protein interaction. BI-0282 shows good permeability and cellular potency and is suitable for oral dosing in in vivo studies.
BI1543673 is a potent and selective IRAK4 inhibitor suitable for both in vitro as well as in vivo use. BI-4326, a structurally close analog, is available as a negative control.