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BIIL 315 is a highly potent LTB4 receptor antagonist (Ki = 1.9 nM).1 It is the active metabolite of the in vivo tool compound BIIL 284 and is the ideal tool to study LTB4 antagonism in vitro.
BI-0588 is one of the most potent and specific allosteric inhibitors of Hepatitis C Virus (HCV) polymerase known, as demonstrated by its cell-based antiviral replicon activity in the single-digit nM range for genotype(GT)-1.
BI-4752 and BI-3234 are potent 5-HT2C receptor agonists, with good in vivo PK profiles in rodents. BI-4752 and BI-3234 reduced food intake in db/db mice at a 100 mg/kg dose, and body weight was decreased over a 28 days period.
BI 605906 is a potent and highly selective inhibitor of IKKβ. In HeLa cells, BI 605906 effectively blocked the phosphorylation of IkBα and the expression of ICAM-1.
BIBR1532 is a highly potent and selective inhibitor of the human telomerase. With excellent permeability and sufficient metabolic stability, it induces telomere shortening and is suitable for both in vitro and in vivo experiments.