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BI-9774 is a highly potent and selective AMPK activator. It activates all human AMPK isoforms tested as well as rat AMPK (α1β1γ1) with EC50 values below 100 nM. It also shows anti-diabetic efficacy in diabetic rodents.
BI-3257 inhibits replication of HIV-1 with nanomolar potency by inhibiting the assembly of the capsid core of the virus. The negative control BI-3545 is also available.
BI-4916 is an ester prodrug of BI-4924 which is a highly potent inhibitor of PHGDH with good selectivity. We also provide BI-4924 and the negative control BI-5583.
BI-4924 is a highly potent inhibitor of PHGDH with good selectivity. We also provide the cell permeable prodrug BI-4916 which is the ethyl ester of BI-4924 and was used to achieve intracellular enrichment of BI-4924. In addition, we provide the negative control BI-5583.
BI-1046 is a selective and highly potent GPR142 agonist that qualifies for in vivo pharmacology experiments due to its high cellular potency and permeability. A negative control is available (BI-4420).