0
Molecules for free

2 June 2025

The tumor suppressor protein p53, also known as TP53, is a crucial transcription factor that plays a pivotal role in regulating various cellular processes such as cell cycle arrest, DNA repair, and apoptosis. One of the central molecular control mechanisms of p53 activity and stability is its inhibition through the negative regulator MDM2.

10
PostDoc Grants

19 May 2025

Assessing the environmental persistence of active pharmaceutical ingredients (APIs) is crucial for minimizing the ecological footprint across every stage of a medicine's lifecycle. Boehringer Ingelheim Animal Health prioritizes sustainability by integrating frameworks like Safe and Sustainable by Design (SSbD) and Green Chemistry Principles into parasiticide drug design, mirroring human pharmaceutical development processes encompassing hit finding, lead optimization, and candidate development.

44
Molecules for free

14 April 2025

Toll-like receptors (TLRs) are important in initiating inflammatory signaling in the lungs in response to pathogens and environmental triggers. Bacterial lipopolysaccharide (LPS) primarily activates TLR4, while viral stimuli preferentially engage TLR7/8. Previous pre-clinical studies have demonstrated that stimulating TLR4 and TLR7/8 ...

23
PostDoc Grants

31 March 2025

We are offering an exceptional PostDoc grant to develop 3D-generative models and apply these for potency predictions with the aim to accelerate drug design. This unique opportunity provides highly talented individuals the chance to pursue their own postdoctoral project proposal within the cutting-edge scientific environment of Boehringer Ingelheim's computational chemistry team in Biberach, Germany.

52
Molecules for free

17 March 2025

Glutamate is a vital central nervous system neurotransmitter that plays a role in various neuronal functions. The metabotropic glutamate receptors (mGluRs) regulate glutamate release and signaling pathways. Among these receptors, mGluR2, a receptor highly expressed in limbic regions throughout the brain, functions as an auto-receptor at pre-synaptic terminals.

Discover us

Hear from our collaborators

slide 1 to 2 of 13