36
Collaborate with us

03 March 2025

N-methyl-D-aspartate receptors (NMDARs) are tetrameric ion channels that play critical roles in the development and function of the central nervous system and have been extensively studied. Conventional NMDARs, composed of two GluN1 and two GluN2 subunits, require glutamate and glycine for their activation, which is essential for neuronal plasticity and regulation of synaptic strength.

18
Molecules for free

10 February 2025

The human ATP-binding cassette transporter subfamily C (ABCC) consists of 12 integral membrane proteins. Among them, nine proteins (ABCC1-ABCC6, ABCC10-ABCC12) form the multidrug resistance protein subfamily. These MRP proteins are widely expressed in the body. MRP4, for instance, is expressed in various tissues and organs, including the brain, liver, and kidney.

87
Collaborate with us

31 January 2025

As part of a recent collaboration which arouse from one of opnMe’s Molecule for collaboration projects, we had the chance to speak to Carla Castellar Álvarez, scientific manager at Nanomol Technologies in Spain. The company specializes in delivering advanced solutions to obtain high-added value products by particle design and nanoformulation1.

32
Collaborate with us

27 January 2025

The reciprocal interaction between the intestinal tract and the liver, the gut-liver axis, is known to play a crucial role in maintaining hepatic homeostasis and function. Perturbation of this bidirectional crosstalk through an impaired intestinal barrier is observed in chronic liver disease and involves inflammation and tissue remodeling.

79
Molecules for free

20 January 2025

Voltage-gated Na+ channels (Nav1.1 – Nav1.9) are transmembrane proteins involved in the conduction of sodium ions and action potential initiation and propagation. They play a crucial role in the function of excitable tissues in the central nervous system, peripheral nervous system, heart, skeletal muscle, and nociceptive signaling.

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Hear from our collaborators

It has been a pleasure for me to participate in opnMe. In addition to providing funding for our research project, it has given my lab an opportunity to collaborate with excellent people at Boehringer Ingelheim, generated some exciting results, and taught us new things about brain circuitry.

Senior Investigator, Temasek Life Sciences Laboratory, Singapore

opnMe has allowed us to showcase the potential of our novel subcutaneous drug delivery platform. They provided clinically relevant "beyond the rule of 5" compounds, which we successfully formulated. Their expert input during meetings was invaluable in advancing the research towards solving challenges of difficult to formulate compounds.

Scientific Manager at Nanomol Technologies, Spain

With the help of opnMe, we teamed up with Boehringer Ingelheim to develop a human-in-the-loop AI solution for pre-clinical research. We’re excited to see the tool in active use, having a measurable positive impact on the daily work of the scientists and increasing the safety of drug discovery.

CTO, Merantix Momentum GmbH, Berlin

opnMe represents a great concept of open science in two ways: It allows Boehringer to stimulate research at the forefront of scientific discovery within a well-defined disease area and it allows academics to excel by approaching Boehringer Ingelheim with proactive, innovative ideas.

Vice President Research, ETH Zurich

The investigation of pancreatic islet regeneration has been central to my lab's research. My collaboration with Boehringer Ingelheim, mediated by its open innovation portal opnMe, has provided us with access to unique reagents and resources and enabled rapid progress over the past two years.

Assistant Professor, Biomedical Research Foundation, Academy of Athens

opnMe has significantly advanced our research on the therapeutic potential of SOS1 deletion or inhibition in KRAS-driven and other RAS-dependent malignancies. By providing access to critical compounds, opnMe has enabled us to conduct studies that assess safety and efficacy of single and dual SOS1/SOS2 inhibition.

Associate Professor, University of Torino, Italy

opnMe's expert guidance was pivotal in forging our research collaboration with Boehringer Ingelheim. Their initiative seamlessly bridged the gap between academic and industry research, uniting foundational biomedical science with application-oriented translational animal health research.

Associate Professor, City University of Hong Kong

opnMe helped us create a collaboration with a team at Boehringer that had designed an IDO inhibitor, leading to many fruitful interactions. It is a real team effort between my lab at Yale and the scientists at Boehringer. I am so hoping that this can lead to a true treatment for many patients.

Professor, Yale School of Medicine

As an academic postdoc, opnMe provided me with the opportunity to apply my skills in a "semi-industry" setting. Collaborating with Boehringer Ingelheim’s experts on pharmacologically relevant questions in neuroscience was particularly exciting, as it aligns with my deep passion for the field.

Senior Research Fellow, Temasek Life Sciences Laboratory, Singapore

As an expert in SOS1/2 biology and tumorigenesis, I was pleased to see the opnMe call for novel hypotheses around SOS1::KRAS. It was the starting point that led to a productive research collaboration and now culminated into a high-profile publication.

Associate Professor, USUHS Bethesda

opnMe facilitated an efficient research partnership with Boehringer Ingelheim, accelerating the discovery of bioactive peptides. opnMe enabled us to combine expertise and resources, therefore leveraging the strengths of both organizations to achieve innovative outcomes.

CMO, PXBioVisioN GmbH, Hannover

opnMe has been instrumental in advancing our research in retinal diseases by providing access to a unique compound for IL1RAP inhibition and facilitating a successful partnership with Boehringer Ingelheim. Our experience with the team has been professional, enjoyable, and resulted in fruitful outcomes.

Professors, Queen’s University Belfast

I found the opnMe portal very easy to navigate and use. The application process is straightforward; this can be achieved in one afternoon. The time from submission to decision is one of the fastest turnarounds I have had, and this aspect makes a real difference in the momentum of pursuing a scientific idea.

Associate Professor, University College London