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02 April 2024

Watch the recording of our opnMe online seminar from March 21, 2024, and follow the journey of our selective MMP-13 inhibitor from our bench to scientific research labs around the world. Learn how BI-4394 helped to shed light on the role of MMP-13...

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Molecules for free

04 March 2024

Orexins or hypocretins are two neuropeptides (OX-A and OX-B) that are synthesized in the hypothalamus, and serve as ligands for the G protein-coupled receptors OX1 and OX2. While the role of orexins was initially thought to be limited to the regulation of...

44
Molecules for free

19 February 2024

Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the central nervous system (CNS), exerting its effects via two classes of receptors, GABAA and GABAB. GABAA receptors (GABAARs) are ligand-gated ion channels typically...

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Molecules for free

22 January 2024

GPR88 is a G-protein coupled receptor (GPCR) expressed primarily in the GABAergic medium spiny neurons of the striatum, and to a lesser extent in the cerebral cortex, amygdala, and hypothalamus. Although its exact function and endogenous ligands are...

39
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05 June 2023

In the first edition of our new opnMe series, Katherine Donovan introduces the Degradation Proteomics Initiative (DPI) that she has established within Eric Fischer’s lab to provide an independent quality assessment of publicly available molecular...

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Hear from our collaborators

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