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Molecules for free

22 January 2024

GPR88 is a G-protein coupled receptor (GPCR) expressed primarily in the GABAergic medium spiny neurons of the striatum, and to a lesser extent in the cerebral cortex, amygdala, and hypothalamus. Although its exact function and endogenous ligands are...

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05 June 2023

In the first edition of our new opnMe series, Katherine Donovan introduces the Degradation Proteomics Initiative (DPI) that she has established within Eric Fischer’s lab to provide an independent quality assessment of publicly available molecular...

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20 January 2023

Watch the recording of our opnMe online seminar from Nov 29, 2022, and follow the journey of the PROTAC ACBI1, a cooperative degrader of BAF subunits SMARCA2 and 4, which are essential parts of the chromatin remodeler BAF (SWI/SNF) complex.

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08 March 2021

The mystery of BI-3802’s BCL6 induced protein degradation is finally solved! The unique mode of action was recently published and received a lot of publicity. Please attend our joined seminar, where Mikołaj Słabicki, Hojong Yoon, and Jonas Koeppel...

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