4
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30 June 2025

The Slowpoke 1 (SLO-1) channel is a large-conductance calcium- and voltage-activated potassium channel and a homotetrameric member of the evolutionarily conserved K+ channel family. Activated by cellular depolarization and cytosolic calcium, SLO-1 plays a critical role in regulating cell excitability and neurotransmitter release.

10
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2 June 2025

The tumor suppressor protein p53, also known as TP53, is a crucial transcription factor that plays a pivotal role in regulating various cellular processes such as cell cycle arrest, DNA repair, and apoptosis. One of the central molecular control mechanisms of p53 activity and stability is its inhibition through the negative regulator MDM2.

44
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14 April 2025

Toll-like receptors (TLRs) are important in initiating inflammatory signaling in the lungs in response to pathogens and environmental triggers. Bacterial lipopolysaccharide (LPS) primarily activates TLR4, while viral stimuli preferentially engage TLR7/8. Previous pre-clinical studies have demonstrated that stimulating TLR4 and TLR7/8 ...

52
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17 March 2025

Glutamate is a vital central nervous system neurotransmitter that plays a role in various neuronal functions. The metabotropic glutamate receptors (mGluRs) regulate glutamate release and signaling pathways. Among these receptors, mGluR2, a receptor highly expressed in limbic regions throughout the brain, functions as an auto-receptor at pre-synaptic terminals.

21
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10 February 2025

The human ATP-binding cassette transporter subfamily C (ABCC) consists of 12 integral membrane proteins. Among them, nine proteins (ABCC1-ABCC6, ABCC10-ABCC12) form the multidrug resistance protein subfamily. These MRP proteins are widely expressed in the body. MRP4, for instance, is expressed in various tissues and organs, including the brain, liver, and kidney.

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