Success examples
Inhibition of RAS-driven signaling and tumorigenesis with a pan-RAS monobody targeting the Switch I/II pocket

Wallon L., Khan I., Teng K. W., Koide A., Zuberi M., Li J., Ketavarapu G., Traaseth N. J., O'Bryan J. P., Koide S.

Proc Natl Acad Sci U S A 2022, 119(43):e2204481119.

KRAS switch I/II pocket inhibitor
DOI
PubMed
Success examples
Functional genomic analysis of epithelioid sarcoma reveals distinct proximal and distal subtype biology

Rasmussen S. V., Jin J. X., Bickford L. R., Woods A. D., Sahm F., Crawford K. A., Nagamori K., Goto H., Torres K. E., Sidoni A., Rudzinski E. R., Thway K., Jones R. L., Ciulli A., Wright H., Lathara M., Srinivasa G., Kannan K., Huang P. H., Grünewald T. P. G., Berlow N. E., Keller C.

Clin Transl Med 2022, 12(7):e961. open access

BRD7/BRD9 PROTAC
DOI
PubMed
Success examples
Cell-free Hemoglobin-Oxidized LDL Axis Contributes to Microvascular Endothelial Barrier Dysfunction and Poor Outcomes During Sepsis

Meegan J. E., Tomasek T., Desco A., Ware L. B., Bastarache J. A.

The FASEB Journal 2022, Vol. 36, No. 1. open access.

LOX-1 inhibitor
DOI
Success examples
Designing Soluble PROTACs: Strategies and Preliminary Guidelines

Jiménez D. G., Sebastiano M. R., Vallaro M., Mileo V., Pizzirani D., Moretti E., Ermondi G., Caron G.

J Med Chem 2022, 65(19):12639-12649.

PTK2 PROTAC PTK2 PROTAC
DOI
PubMed
Success examples
BTB BCL6 dimers as building blocks for reversible drug-induced protein oligomerization

Nitsch L., Jensen P., Yoon H., Koeppel J., Burman S. S. R., Fischer E. S., Scholl C., Fröhling S., Słabicki M.

Cell Rep Methods 2022, 2(4):100193.

BCL6 degrader BCL6 inhibitor BCL6 degrader
DOI
PubMed
Success examples
Identification of Sodium Transients Through Na V 1.5 Channels as Regulators of Differentiation in Immortalized Dorsal Root Ganglia Neurons

Martínez A. L., Brea J., Domínguez E., Varela M. J., Allegue C., Cruz R., Monroy X., Merlos M., Burgueño J., Carracedo A., Loza M. I.

Front Cell Neurosci 2022, 16:816325. open access

Nav1.2 channel blocker
DOI
PubMed