Success examples
Focal Adhesion Kinase Binds to the HPV E2 Protein to Regulate Initial Replication after Infection

Jose L., Gonzalez J., Kessinger E., Androphy E. J., DeSmet M.

Pathogens 2023, 12(10), 1203.

PTK2 PROTAC
DOI
Success examples
Which Small Molecule? Selecting Chemical Probes for Use in Cancer Research and Target Validation

Mader M. M., Rudolph J., Hartung I. V., Uehling D., Workman P., Zuercher W.

Cancer Discov. 2023, 13(10):2150-2165.

SMARCA2 PROTAC
DOI
PubMed
Success examples
Development and Characterization of Selective FAK Inhibitors and PROTACs with In Vivo Activity

Koide E., Mohardt M. L., Doctor Z. M., Yang A., Hao M., Donovan K. A., Kuismi C. C., Nelson A. J., Abell K., Aguiar M., Che J., Stokes M. P., Zhang T., Aguirre A. J., Fischer E. S., Gray N. S., Jiang B., Nabet B.

Chembiochem. 2023, 24(19):e202300141.

PTK2 PROTAC PTK2 PROTAC
DOI
PubMed
Success examples
Hydroxyproline metabolism enhances IFN-γ-induced PD-L1 expression and inhibits autophagic flux

Spangenberg S. H., Palermo A., Gazaniga N. R., Martínez-Peña F., Guijas C., Chin E. N., Rinschen M. M., Sander P. N., Webb B., Pereira L. E., Jia Y., Meitz L., Siuzdak G., Lairson L. L.

Cell Chem Biol. 2023, 30(9):1115-1134.e10.

IKKβ inhibitor
DOI
PubMed
Success examples
Chamelogk: A Chromatographic Chameleonicity Quantifier to Design Orally Bioavailable Beyond-Rule-of-5 Drugs

Jimenez D. G., Vallaro M., Rossi Sebastiano M., Apprato G., D'Agostini G., Rossetti P., Ermondi G., Caron G.

J Med Chem. 2023, 66(15):10681-10693.

BET PROTAC
DOI
PubMed
Success examples
Expanding Chemical Probe Space: Quality Criteria for Covalent and Degrader Probes

Hartung I. V., Rudolph J., Mader M. M., Mulder M. P. C., Workman P.

J Med Chem. 2023, 66(14):9297-9312.

SMARCA2 PROTAC
DOI
PubMed