Success examples
Deaminative chlorination of aminoheterocycles

Ghiazza C., Faber T., Gómez-Palomino A., Cornella J.

Nat Chem 2022, (1):78-84.

FLAP antagonist
DOI
PubMed
Success examples
Establishment and Evaluation of Dual HDAC/BET Inhibitors as Therapeutic Options for Germ Cell Tumors and Other Urological Malignancies

Burmeister A., Stephan A., Alves Avelar L. A., Müller M. R., Seiwert A., Höfmann St., Fischer F., Torres-Gomez H., Hoffmann M. J., Niegisch G., Bremmer F., Petzsch P., Köhrer K., Albers P., Kurz T., Skowron M. A., Nettersheim D.

Mol Cancer Ther 2022, 21(11):1674-1688.

BET PROTAC
DOI
PubMed
Success examples
Basophil activation test: Assay precision and BI 1002494 SYK inhibition in healthy and mild asthmatics

Carstensen S., Benediktus E., Litzenburger T., Hohlfeld J. M., Müller M.

Cytometry A 2022, 101(1):86-94.

SYK inhibitor
DOI
PubMed
Success examples
Enhancing delivery of poorly water-soluble drugs by innovative amorphous solid dispersions

Jermain S. V.

The University of Texas at Austin 2019.

CCR1 antagonist
DOI