Success examples
Transcriptional Antagonism by CDK8 Inhibition Improves Therapeutic Efficacy of MEK Inhibitors

Malone C. F., Kim M., Alexe G., Engel K., Forman A. B., Robichaud A., Saur Conway A., Goodale A., Meyer A., Khalid D., Thayakumar A., Hatcher J. M., Gray N. S., Piccioni F., Stegmaier K.

Cancer Res 2023, 83(2):285-300.

Success examples
Functional E3 ligase hotspots and resistance mechanisms to small-molecule degraders

Hanzl A., Casement R., Imrichova H., Hughes S. J., Barone E., Testa A., Bauer S., Wright J., Brand M., Ciulli A., Winter G. E.

Nat Chem Biol 2022, 61(2):599-618.

Success examples
Inhibition of RAS-driven signaling and tumorigenesis with a pan-RAS monobody targeting the Switch I/II pocket

Wallon L., Khan I., Teng K. W., Koide A., Zuberi M., Li J., Ketavarapu G., Traaseth N. J., O'Bryan J. P., Koide S.

Proc Natl Acad Sci U S A 2022, 119(43):e2204481119.

Success examples
Functional genomic analysis of epithelioid sarcoma reveals distinct proximal and distal subtype biology

Rasmussen S. V., Jin J. X., Bickford L. R., Woods A. D., Sahm F., Crawford K. A., Nagamori K., Goto H., Torres K. E., Sidoni A., Rudzinski E. R., Thway K., Jones R. L., Ciulli A., Wright H., Lathara M., Srinivasa G., Kannan K., Huang P. H., Grünewald T. P. G., Berlow N. E., Keller C.

Clin Transl Med 2022, 12(7):e961. open access

Success examples
Cell-free Hemoglobin-Oxidized LDL Axis Contributes to Microvascular Endothelial Barrier Dysfunction and Poor Outcomes During Sepsis

Meegan J. E., Tomasek T., Desco A., Ware L. B., Bastarache J. A.

The FASEB Journal 2022, Vol. 36, No. 1. open access.

Success examples
Designing Soluble PROTACs: Strategies and Preliminary Guidelines

Jiménez D. G., Sebastiano M. R., Vallaro M., Mileo V., Pizzirani D., Moretti E., Ermondi G., Caron G.

J Med Chem 2022, 65(19):12639-12649.