Success examples
Identification of novel azaindazole CCR1 antagonist clinical candidates

Harcken C., Kuzmich D., Cook B., Mao C., Disalvo D., Razavi H., Swinamer A., Liu P., Zhang Q., Kukulka A., Skow D., Patel M., Patel M., Fletcher K., Sherry T., Joseph D., Smith D., Canfield M., Souza D., Bogdanffy M., Berg K., Brown M.

Bioorganic & Medicinal Chemistry Letters 2019, 29, 441-448.

CCR1 antagonist
DOI
PubMed
Success examples
Corticosteroids inhibit Mycobacterium tuberculosis-induced necrotic host cell death by abrogating mitochondrial membrane permeability transition

Gräb J., Suárez I., van Gumpel E., Winter S., Schreiber F., Esser A., Hölscher C., Fritsch M., Herb M., Schramm M., Wachsmuth L., Pallasch C., Pasparakis M., Kashkar H., Rybniker J.

Nat. Commun. 2019, 10, 688

Glucocorticoid Receptor (GR) Agonist
DOI
PUBMED