Success examples
SMARCA4 biology in alveolar rhabdomyosarcoma

Bharathy N., Cleary M. M., Kim J-A., Nagamori K., Crawford K. A., Wang E., Saha D., Settelmeyer T. P., Purohit R., Skopelitis D., Chang K., Doran J. A., Kirschbaum C. W., Bharathy S., Crews D. W., Randolph M. E., Karnezis A. N., Hudson-Price L., Dhawan J., Michalek J. E., Ciulli A., Vakoc C. R., Keller C.

Oncogene 2022, 41(11):1647-1656.

Success examples
Pharmacological Dissection of the Crosstalk between NaV and CaV Channels in GH3b6 Cells

Réthoré L., Park J., Montnach J., Nicolas S., Khoury J., Le Seac'h E., Mabrouk K., De Pomyers H., Tricoire-Leignel H., Mattei C., Henrion D., Fajloun Z., De Waard M., Legendre C., Legros C.

Int J Mol Sci. 2022, 23 (2):827.

Success examples
The bromodomain and extra-terminal domain degrader MZ1 exhibits preclinical anti-tumoral activity in diffuse large B-cell lymphoma of the activated B cell-like type

Tarantelli C., Cannas E., Ekeh H., Moscatello C., Gaudio E., Cascione L., Napoli S., Rech C., Testa A., Maniaci C., Rinaldi A., Zucca E., Stathis A., Ciulli A., Bertoni F.

Explor Target Antitumor Ther. 2021, 2:586-601.

Success examples
Characterizing PROTAC ternary complex formation using Biacore™ SPR systems

Zollman D., Shepherd C., Cytiva, Ciulli A.

Cytiva.

Success examples
Into Deep Water: Optimizing BCL6 Inhibitors by Growing into a Solvated Pocket

Lloyd M. G., Huckvale R., Cheung K-M. J., Rodrigues M. J., Collie G. W., Pierrat O. A., Iou M. G., Carter M., Davis O. A., McAndrew P. C., Gunnell E., Le Bihan Y-V., Talbot R., Henley A. T., Johnson L. D., Hayes A., Bright M. D., Raynaud F. I., Meniconi M., Burke R., van Montfort R. L. M., Rossanese O. W., Bellenie B. R., Hoelder S.

J Med Chem. 2021, 64, 23, 17079-17097.

Success examples
Frequent mutations of FBXO11 highlight BCL6 as a therapeutic target in Burkitt lymphoma

Pighi C., Cheong T.C., Compagno M., Patrucco E., Arigoni M., Olivero M., Wang Q., Lopez C., Bernhart S.H., Grande B.M., Poggio T., Langellotto F., Bonello L., Dall'Olio R., Martinez-Martin S., Molinaro L., Francia di Celle P., Whitfield J.R., Soucek L., Voena C., Calogero R.A., Morin R.D., Staudt L.M., Siebert R., Zamo A., Chiarle R.

Blood Adv 2021, 5(23):5239-5257.