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BI-5756 is a potent and polar cholesteryl ester transfer protein (CETP) inhibitor with reduced lipophilicity and improved solubility compared to other CETP inhibitors. It has a fast elimination from fat tissues of hCETP transgenic mice.
BI-5524 is a highly potent and selective inhibitor of human Neutrophil Elastase with a favourable pharmacokinetic (PK) profile suited for in vivo studies.
BIX 02565 is a highly potent inhibitor of the ribosomal S6 kinase (RSKs) isoforms and has been extensively characterized on a standardized selectivity panel. It further demonstrates inhibition of adrenergic receptor subtypes and the imidazoline I2 receptor.
BIBO3304 is a potent and selective in vitro and in vivo tool compound. It acts as an antagonist on the neuropeptide Y (NPY) receptor Y1. Its distomer BIBO3457 is available as negative control.
VUBI1 is a potent activator of SOS1 which modulates the KRAS pathway. SOS1 is a guanine exchange factor that acts as biological control protein for KRAS, one of the most important cellular signaling nodes.