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BI-7190 is a probe to study the impact of BPTF bromodomain inhibition in vitro and in vivo. BPTF is a core component of the nucleosome remodelling factor (NURF) complex.
BI 113823 is a potent and selective B1 receptor antagonist that showed analgesic effect in chronic nociceptive pain conditions in preclinical animal models.
BI-5756 is a potent and polar cholesteryl ester transfer protein (CETP) inhibitor with reduced lipophilicity and improved solubility compared to other CETP inhibitors. It has a fast elimination from fat tissues of hCETP transgenic mice.
BI-5524 is a highly potent and selective inhibitor of human Neutrophil Elastase with a favourable pharmacokinetic (PK) profile suited for in vivo studies.
BIX 02565 is a highly potent inhibitor of the ribosomal S6 kinase (RSKs) isoforms and has been extensively characterized on a standardized selectivity panel. It further demonstrates inhibition of adrenergic receptor subtypes and the imidazoline I2 receptor.