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ACBI2 is a highly potent (DC50, 18h, RKO SMARCA2 = 1 nM) and orally bioavailable (Foral, mice = 22%) SMARCA2-VHL PROTAC.
BI-7190 is a probe to study the impact of BPTF bromodomain inhibition in vitro and in vivo. BPTF is a core component of the nucleosome remodelling factor (NURF) complex.
BI 113823 is a potent and selective B1 receptor antagonist that showed analgesic effect in chronic nociceptive pain conditions in preclinical animal models.
BI-5756 is a potent and polar cholesteryl ester transfer protein (CETP) inhibitor with reduced lipophilicity and improved solubility compared to other CETP inhibitors. It has a fast elimination from fat tissues of hCETP transgenic mice.
BI-5524 is a highly potent and selective inhibitor of human Neutrophil Elastase with a favourable pharmacokinetic (PK) profile suited for in vivo studies.