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BI-8128 is a reversible and highly selective, fourth generation EGFR inhibitor suitable for in vitro and in vivo studies with potent activity against the primary oncogenic EGFR variants del19 and L858R as well as the acquired EGFR resistance mutations T790M and C79
BI-3434 is a potent peptidic secretin receptor (SctR) agonist that serves as a high-quality in vitro and in vivo tool compound. The agonist shows high potency with good selectivity and a prolonged half-life in mice.
BI 894999 is a small molecule oral BET inhibitor suitable for in vitro and in vivo studies. BET family proteins are key regulators of transcription. The related molecule BI-6953 is available as a negative control.
BI-9593 is a potent and selective orally bioavailable PHGDH inhibitor. Its high permeability and tolerability render it ideal for in vivo as well as cellular profiling. Its stereoisomer BI-9594 is available as negative control.
With BI-1136, we share an unprecedented, selective orally bioavailable BCL6 degrader with nanomolar potency. The molecule is suitable for in vivo testing in rodents and displays good tolerability.