Success examples
Suppression of the HBP Function Increases Pancreatic Cancer Cell Sensitivity to a Pan-RAS Inhibitor

Ricciardiello F., Bergamaschi L., De Vitto H., Gang Y.,Zhang T., Palorini R., Chiaradonna F.

Cells 2021, 10(2), 431.

KRAS switch I/II pocket inhibitor
DOI
PUBMED
Success examples
Small-molecule-induced polymerization triggers degradation of BCL6

Słabicki M., Yoon H., Koeppel J., Nitsch L., Roy Burman S. S., Di Genua C., Donovan K. A., Sperling A. S., Hunkeler M., Tsai J. M., Sharma R., Guirguis A., Zou C., Chudasama P., Gasser J. A., Miller P. G., Scholl C., Fröhling S., Nowak R. P., Fischer E. S., Ebert B. L.

Nature 2020, 588, 164–168.

BCL6 degrader BCL6 inhibitor BCL6 degrader
DOI
PUBMED
Success examples
In Vitro and In Vivo Behaviors of KinetiSol and Spray-Dried Amorphous Solid Dispersions of a Weakly Basic Drug and Ionic Polymer

Jermain S. V., Lowinger M. B., Ellenberger D. J., Miller D. A., Su Y., Williams III R. O.

Mol. Pharmaceutics 2020, 17, 8, 2789-2808.

CCR1 antagonist
DOI
PUBMED
Success examples
Heterotypic 3D pancreatic cancer model with tunable proportion of fibrotic elements

Hiroyoshi Y. T., Tsuyoshi K., Takuya N., Michiya M., Atsushi M., Mitsunobu R.K.

Biomaterials 2020, 251:120077.

GSK-3 inhibitor
DOI
PubMed