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AXPSP0056 is a selective allosteric GCH1 inhibitor that acts as a mimic of tetrahydrobiopterin (BH4). By occupying the latter’s binding site on GCH1, it triggers a feedback inhibition mechanism that decreases GCH1’s activity in the presence of elevated cellular concentrations of BH4.
BI-0474 is a selective and potent irreversible covalent KRASG12C inhibitor, developed using an NMR-based fragment screening approach pioneered at Vanderbilt University, whereby small molecules that bind reversibly to the KRAS switch II pocket were identified and optimized using structu
Orexins are potent neuropeptides interacting with G protein-coupled receptors known as orexin type-1 and type-2 receptors. BI-5121 is a selective orexin type 1 receptor antagonist with high in vitro potency.
GABA type A receptors are chloride ion channels that drive inhibitory neurotransmission in the mammalian central nervous system upon binding of GABA, the primary inhibitory neurotransmitter in the central nervous system.
BI-9508 is a potent and selective agonist of the G-protein-coupled receptor 88 (GPR88). It displays improved brain penetration properties compared to earlier agonists. The closely related compound BI-0823 is available as a negative control.