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BI-9508 is a potent and selective agonist of the G-protein-coupled receptor 88 (GPR88). It displays improved brain penetration properties compared to earlier agonists. The closely related compound BI-0823 is available as a negative control.
BI-5232 is a drug-like non-natural ligand of the thiM aptamer of the TPP riboswitch with potencies near equal to TPP itself. It has been shown to cellularly induce transgene expression in constructs using both the native aptamer as well as a site-directed mutant which does not bind TPP.
Gram-positive bacteria and mycobacteria utilize a protein degradation system, ClpCP, which acts analogous to the eukaryotic ubiquitin protein degradation machinery.
BI-8128 is a reversible and highly selective, fourth generation EGFR inhibitor suitable for in vitro and in vivo studies with potent activity against the primary oncogenic EGFR variants del19 and L858R as well as the acquired EGFR resistance mutations T790M and C79
BI-3434 is a potent peptidic secretin receptor (SctR) agonist that serves as a high-quality in vitro and in vivo tool compound. The agonist shows high potency with good selectivity and a prolonged half-life in mice.