Success examples
Functional genomic analysis of epithelioid sarcoma reveals distinct proximal and distal subtype biology

Rasmussen S. V., Jin J. X., Bickford L. R., Woods A. D., Sahm F., Crawford K. A., Nagamori K., Goto H., Torres K. E., Sidoni A., Rudzinski E. R., Thway K., Jones R. L., Ciulli A., Wright H., Lathara M., Srinivasa G., Kannan K., Huang P. H., Grünewald T. P. G., Berlow N. E., Keller C.

Clin Transl Med 2022, 12(7):e961. open access

BRD7/BRD9 PROTAC
DOI
PubMed
Success examples
Cell-free Hemoglobin-Oxidized LDL Axis Contributes to Microvascular Endothelial Barrier Dysfunction and Poor Outcomes During Sepsis

Meegan J. E., Tomasek T., Desco A., Ware L. B., Bastarache J. A.

The FASEB Journal 2022, Vol. 36, No. 1. open access.

LOX-1 inhibitor
DOI
General literature
opnMe.com: a digital initiative for sharing tools with the biomedical research community

Gollner A., Köster M., Nicklin P., Trieselmann T., Klein E., Vlach J., Heine C., Grundl M., Ramharter J., Wyatt D., Chaturvedi M., Ciulli A., Carter K. C., Müller S., Bischoff D., Ettmayer P., Haaksma E., Mack J., McConnell D., Stenkamp D., Weinstabl H., Zentgraf M., Wood C. R., Montel F.

Nat. Rev. Drug Discov. 2022, 21:475-476. open access

DOI
PubMed
General literature
Open innovation: A paradigm shift in pharma R&D?

Schuhmacher A., Gassmann O., Bieniok D., Hinder M., Hartl D.

Drug Discov Today 2022, 27:2395-2405.

DOI
PubMed
Success examples
Designing Soluble PROTACs: Strategies and Preliminary Guidelines

Jiménez D. G., Sebastiano M. R., Vallaro M., Mileo V., Pizzirani D., Moretti E., Ermondi G., Caron G.

J Med Chem 2022, 65(19):12639-12649.

PTK2 PROTAC PTK2 PROTAC
DOI
PubMed
Success examples
BTB BCL6 dimers as building blocks for reversible drug-induced protein oligomerization

Nitsch L., Jensen P., Yoon H., Koeppel J., Burman S. S. R., Fischer E. S., Scholl C., Fröhling S., Słabicki M.

Cell Rep Methods 2022, 2(4):100193.

BCL6 degrader BCL6 inhibitor BCL6 degrader
DOI
PubMed