Publications

Success examples

Into Deep Water: Optimizing BCL6 Inhibitors by Growing into a Solvated Pocket

Lloyd M. G., Huckvale R., Cheung K-M. J., Rodrigues M. J., Collie G. W., Pierrat O. A., Iou M. G., Carter M., Davis O. A., McAndrew P. C., Gunnell E., Le Bihan Y-V., Talbot R., Henley A. T., Johnson L. D., Hayes A., Bright M. D., Raynaud F. I., Meniconi M., Burke R., van Montfort R. L. M., Rossanese O. W., Bellenie B. R., Hoelder S.

J Med Chem. 2021, 64, 23, 17079-17097.

BCL6 inhibitor

DOI

PubMed

General literature

Chemical Probes for Understudied Kinases: Challenges and Opportunities

Serafim R. A. M., Elkins J. M., Zuercher W. J., Laufer S. A., Gehringer M.

J Med Chem. 2021, Online ahead of print.

DOI

PubMed

Success examples

Frequent mutations of FBXO11 highlight BCL6 as a therapeutic target in Burkitt lymphoma

Pighi C., Cheong T.C., Compagno M., Patrucco E., Arigoni M., Olivero M., Wang Q., Lopez C., Bernhart S.H., Grande B.M., Poggio T., Langellotto F., Bonello L., Dall'Olio R., Martinez-Martin S., Molinaro L., Francia di Celle P., Whitfield J.R., Soucek L., Voena C., Calogero R.A., Morin R.D., Staudt L.M., Siebert R., Zamo A., Chiarle R.

Blood Adv 2021, 5(23):5239-5257.

BCL6 degrader BCL6 inhibitor BCL6 degrader

DOI

PubMed

General literature

Machine Learning Solicitation for COVID 19

Mohanty S. N., Saxena S. K., Satpathy S., Chatterjee J. M.

Springer 2021, ISBN 978-981-15-7316-3.