Success examples
In Vitro and In Vivo Behaviors of KinetiSol and Spray-Dried Amorphous Solid Dispersions of a Weakly Basic Drug and Ionic Polymer

Jermain S. V., Lowinger M. B., Ellenberger D. J., Miller D. A., Su Y., Williams III R. O.

Mol. Pharmaceutics 2020, 17, 8, 2789-2808.

CCR1 antagonist
DOI
PUBMED
General literature
A precisely positioned MED12 activation helix stimulates CDK8 kinase activity

Klatt F., Leitner A., Kim I. V., Ho-Xuan H., Schneider E. V., Langhammer F., Weinmann R., Müller M. R., Huber R., Meister G., Kuhn C.

PNAS 2020, 117, (6), 2894-2905.

DOI
PUBMED
General literature
A Highly Selective Chemical Probe for Activin Receptor-like Kinases ALK4 and ALK5

Hanke T., Wong J. F., Berger B., Abdi I., Berger L. M., Tesch R., Tredup C., Bullock A. N., Müller S., Knapp S.

ACS Chem. Biol. 2020, 15, (4), 862-870.

DOI
PUBMED
General literature
Discovery of 4-Piperazine Isoquinoline Derivatives as Potent and Brain-Permeable Tau Prion Inhibitors with CDK8 Activity

Grandjean J. M., Jiu A. Y., West J.W., Aoyagi A., Droege D.G., Elepano M., Hirasawa M., Hirouchi M., Murakami R., Lee J., Sasaki K., Hirano S., Ohyama T., Tang B. C., Vaz R. J., Inoue M., Olson S. H., Prusiner S. B., Conrad J., Paras N.A.

ACS Med. Chem. Lett. 2020, 11, (2), 127–132. open access.

PUBMED
General literature
PAINS management: an open source model to eliminate nuisance compounds

Capuzzi S. J., Morris D. C.

Drug Target Review 2018. open access.

DOI