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BI-3434 is a potent peptidic secretin receptor (SctR) agonist that serves as a high-quality in vitro and in vivo tool compound. The agonist shows high potency with good selectivity and a prolonged half-life in mice.
BI 894999 is a small molecule oral BET inhibitor suitable for in vitro and in vivo studies. BET family proteins are key regulators of transcription. The related molecule BI-6953 is available as a negative control.
BI-9593 is a potent and selective orally bioavailable PHGDH inhibitor. Its high permeability and tolerability render it ideal for in vivo as well as cellular profiling. Its stereoisomer BI-9594 is available as negative control.
With BI-1136, we share an unprecedented, selective orally bioavailable BCL6 degrader with nanomolar potency. The molecule is suitable for in vivo testing in rodents and displays good tolerability.
BI-3231 is potent and selective inhibitor of hydroxysteroid 17-beta dehydrogenase 13 (HSD17B13), a lipid droplet-associated enzyme primarily expressed in hepatocytes and whose exact function and substrates are unknown.